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YTHDF2 Rekombinanter Antikörper
YTHDF2 Rekombinant Antikörper für WB, IF/ICC, IP, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus, Ratte
Anwendung
WB, IF/ICC, IP, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
3L6
Kat-Nr. : 81340-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
81340-1-PBS bindet in WB, IF/ICC, IP, Indirect ELISA YTHDF2 und zeigt Reaktivität mit human, Maus, Ratten
Getestete Reaktivität | human, Maus, Ratte |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | YTHDF2 fusion protein Ag5922 |
Vollständiger Name | YTH domain family, member 2 |
Berechnetes Molekulargewicht | 62 kDa |
Beobachtetes Molekulargewicht | 65-70 kDa |
GenBank-Zugangsnummer | BC002559 |
Gene symbol | YTHDF2 |
Gene ID (NCBI) | 51441 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
YTHDF2, also named as YTH domain-containing family protein 2, is a 579 amino acid protein, which contains 1 YTH domain. YTHDF2 specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. YTHDF2 acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. YTHDF2 also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation. The calculated molecular weight of YTHDF2 is 62 kDa, but the phosphorylated YTHDF2 is about 65-70 kDa.