ZBTB17 Polyklonaler Antikörper

ZBTB17 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

Konjugation

Unkonjugiert

Kat-Nr. : 22691-1-AP

Synonyme

MIZ 1, MIZ1, pHZ 67, Zinc finger protein 151, Zinc finger protein 60

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  WB analysis using 22691-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22691-1-AP (ZBTB17 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 22691-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22691-1-AP (ZBTB17 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Jurkat-Zellen, NIH/3T3-Zellen, THP-1-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:5000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

22691-1-AP bindet in ZBTB17 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ZBTB17 fusion protein Ag18396
• Vollständiger Name: zinc finger and BTB domain containing 17
• Berechnetes Molekulargewicht: 803 aa, 88 kDa
• Beobachtetes Molekulargewicht: 88-100 kDa
• GenBank-Zugangsnummer: BC126163
• Gene symbol: ZBTB17
• Gene ID (NCBI): 7709
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-affinitätsgereinigt
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ZBTB17 (zinc finger and BTB domain protein 17), also known as MIZ1, is a highly conserved transcription factor in evolution. It is expressed in many cell types and plays an important role in many biological processes such as cell cycle regulation, immune cell development and metabolic regulation. ZBTB17 plays a key role in the early stage of T cell development. It ensures the normal development of T cells by regulating the expression of pre-TCR and inhibiting the activity of TP53. ZBTB17 plays an important role in cardiac stress response, and its absence may lead to cardiomyopathy and heart failure. At Lys-397 and Lys-481, it undergoes "Lys-48" linked ubiquitination, and then degrades proteasome in a TRAF2-dependent manner.