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ZFP64 Rekombinanter Antikörper

ZFP64 Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

240847F9

Kat-Nr. : 83825-3-PBS

Synonyme

ZNF338, Zinc finger protein 64, Zfp-64, Zfp 64, 240847F9

Filter:
  • Western Blot (WB) analysis of various lysates using ZFP64 Recombinant antibody (83825-3-RR)

    WB analysis using 83825-3-RR (same clone as 83825-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83825-3-RR (ZFP64 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83825-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83825-3-RR

    Affinity and Kinetic Characterization of 83825-3-RR

    Biolayer interferometry (BLl) kinetic assays of 83825-3-RR against Human ZFP64 were performed. The affinity constant is 1.53 nM.

Geprüfte Anwendungen

Produktinformation

83825-3-PBS bindet in WB, ELISA ZFP64 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen ZFP64 fusion protein Ag10971
Vollständiger Name zinc finger protein 64 homolog (mouse)
Berechnetes Molekulargewicht 681 aa, 75 kDa
Beobachtetes Molekulargewicht 70 kDa
GenBank-ZugangsnummerBC041622
Gene symbol ZFP64
Gene ID (NCBI) 55734
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ZFP64 (also known as ZNF338) is a member of the Krüppel C2H2-type zinc finger family. ZFP64 is a coactivator of Notch1, mediating mesenchymal cell differentiation. ZFP64 expression was up-regulated in mouse peritoneal macrophages in response to stimulation with the TLR4 ligand LPS with a 2-fold increase. The MLL gene encoding the MLL fusion protein is easily activated by ZFP64. ZFP64 is essential for the continuous production of MLL fusion proteins in blood cancer and produces more cancer cells. Since ZFP64 deletion completely and specifically inhibits MLL fusion protein production and leukemia cascade growth, it is an ideal drug target.