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ZNF238/ZBTB18 Rekombinanter Antikörper

ZNF238/ZBTB18 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251389B9

Kat-Nr. : 86544-3-PBS

Synonyme

ZNF238, 58 kDa repressor protein, C2H2 171, RP58, TAZ 1

Filter:
  • Western Blot (WB) analysis of various lysates using ZNF238/ZBTB18 Recombinant antibody (86544-3-RR)

    WB analysis using 86544-3-RR (same clone as 86544-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86544-3-RR (ZNF238 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86544-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86544-3-RR

    Affinity and Kinetic Characterization of 86544-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86544-3-RR against Human ZNF238/ZBTB18 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86544-3-PBS bindet in WB, Indirect ELISA ZNF238/ZBTB18 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen ZNF238/ZBTB18 fusion protein Ag3406
Vollständiger Name zinc finger protein 238
Berechnetes Molekulargewicht 531 aa, 59 kDa
Beobachtetes Molekulargewicht 48 kDa
GenBank-ZugangsnummerBC036677
Gene symbol ZNF238/ZBTB18
Gene ID (NCBI) 10472
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ZNF238 is a member of the BTB/POZ-ZF protein family, which involve in development and cancer formation, for example BCL-6, PLZF, and HIC-1. It's a transcriptional repressor involve in myogenesis and brain development. By directly repressing the expression of two skeletal myogenesis inhibitors, ID2 and ID3, ZNF238 plays a key role in myogenesis. It can control cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Besides, ZNF238 involves in the organization of nuclear chromosomes, for its specific binding to the consensus DNA sequence that contains the E box core, and recruiting chromatin remodeling multi-protein complex. ZNF238 proteins has apparent molecular masses of 60 and 48 kD. Specific binding is found for a 60-kDa band which corresponds to the full length of RP58 protein. In addition, a 48-kDa band, thought to be the truncated form 2 is detected (PMID: 9756912).