ZNF410 Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

ZNF410 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, ChIP, ELISA

Konjugation

Unkonjugiert

Publikationen(7)

Kat-Nr. : 14529-1-AP

Synonyme

Zinc finger protein APA 1, Zinc finger protein 410, APA1, APA 1, Another partner for ARF 1

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  WB analysis using 14529-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 14529-1-AP (ZNF410 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 14529-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 14529-1-AP (ZNF410 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HEK-293-Zellen, HeLa-Zellen, MCF-7-Zellen, Maushirngewebe, U2OS-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 7 publications below
• ChIP: See 1 publications below

Produktinformation

14529-1-AP bindet in WB, ChIP, ELISA ZNF410 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ZNF410 fusion protein Ag6028
• Vollständiger Name: zinc finger protein 410
• Berechnetes Molekulargewicht: 52 kDa
• Beobachtetes Molekulargewicht: 52-67 kDa
• GenBank-Zugangsnummer: BC050683
• Gene symbol: ZNF410
• Gene ID (NCBI): 57862
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ZNF410 (Zinc Finger Protein 410) is a transcription factor involved in the regulation of gene expression, particularly in the context of fetal hemoglobin (HbF) repression and chromatin remodeling. This protein is highly conserved among mammals and plays a crucial role in erythroid cells. The study found that ZNF410 uniquely silences HbF by activating its sole target gene, CHD4, a known HbF repressor in erythroid cells. (PMID: 40158221)

Publikationen

Species	Application	Title
human	WB	Nat Genet; ZNF410 represses fetal globin by singular control of CHD4.; Authors - Divya S Vinjamur ; KO Validated
human	WB	Mol Cell; ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.; Authors - Xianjiang Lan
mouse	WB	EMBO J; PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.; Authors - Xixi Tao
human	WB	Mol Ther; Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies.; Authors - Boya Liu
human	WB	Biomedicines; Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin.; Authors - Hsien-Lin Chen
mouse	WB	Free Radic Biol Med; Critical role of caveolin-1 in intestinal ischemia reperfusion by inhibiting protein kinase C βII; Authors - Zhao Chen