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ZNF746 Polyklonaler Antikörper

ZNF746 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24543-1-PBS

Synonyme

Zinc finger protein 746, Parkin-interacting substrate, PARIS, FLJ31413

Filter:
  • Western Blot (WB) analysis of various lysates using ZNF746 Polyclonal antibody (24543-1-AP)

    WB analysis using 24543-1-AP (same clone as 24543-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24543-1-AP (ZNF746 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24543-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HEK-293T cells using ZNF746 Polyclonal antibody (24543-1-AP)

    WB analysis of HEK-293T using 24543-1-AP (same clone as 24543-1-PBS)

    HEK-293T cells were subjected to SDS PAGE followed by western blot with 24543-1-AP (ZNF746 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24543-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24543-1-PBS bindet in WB, Indirect ELISA ZNF746 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ZNF746 fusion protein Ag21566
Vollständiger Name zinc finger protein 746
Berechnetes Molekulargewicht 644 aa, 69 kDa
Beobachtetes Molekulargewicht 85-95 kDa
GenBank-ZugangsnummerBC068505
Gene symbol ZNF746
Gene ID (NCBI) 155061
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN (PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).