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NeutraKine® Beta NGF Monoklonaler Antikörper

NeutraKine® Beta NGF Monoklonal Antikörper für Neutralization, ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

Neutralization, ELISA

Konjugation

Unkonjugiert

CloneNo.

4F9H1

Kat-Nr. : 69009-1-Ig

Synonyme

Beta nerve growth factor, Beta NGF, HSAN5, NeutraKine® Beta NGF, NGF, NGFB, proNGF

Galerie der Validierungsdaten

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  • Neutralization experiment of NeutraKine® Beta NGF using NeutraKine® Beta NGF Monoclonal antibody (69009-1-Ig)

    Neutralization experiment of NeutraKine® Beta NGF using 69009-1-Ig

    Recombinant human beta-NGF (Cat.NO. HZ-1222) stimulates proliferation of TF-1 cell line (human erythroleukemic cell line) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human beta-NGF (2 ng/mL HZ-1222) is neutralized by mouse anti-human beta-NGF monoclonal antibody 69009-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 4-20 ng/mL.

NeutralizationMeasured by its ability to neutralize Human beta-NGF induced proliferation of TF-1 cell line (human erythroleukemic cell line) . The half neutralization dose (ND50) is typically 4-20 ng/mL in the presence of 2 ng/mL human beta-NGF.

Produktinformation

69009-1-Ig bindet in Neutralization, ELISA NeutraKine® Beta NGF und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen human Humankine Beta NGF protein HZ-1222
Vollständiger Name nerve growth factor (beta polypeptide)
Gene symbol NGF
Gene ID (NCBI) 4803
Konjugation Unkonjugiert
Form Lyophilized Powder
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer Sterile PBS.
Endotoxin<0.1 EU/μg
WiederherstellungThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Hintergrundinformationen

Beta nerve growth factor (NGF) is critical for the survival and maintenance of sympathetic and sensory neurons and may play an important role in the regulation of the immune system (PMID 16842161). The presence of beta NGF in immune cells, endocrine cells, and the CNS limbic areas suggests that beta NGF may function as an intracellular messenger to regulate the body's response to stress (PMID 19442684).

This antibody can be used to neutralize the bioactivity of Beta NGF.