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gp130/IL6ST Rekombinanter Antikörper

gp130/IL6ST Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242236E1

Kat-Nr. : 84794-4-PBS

Synonyme

242236E1, CD130, gp130, IL-6 receptor subunit beta, IL-6R subunit beta

Filter:
  • Western Blot (WB) analysis of various lysates using gp130/IL6ST Recombinant antibody (84794-4-RR)

    WB analysis using 84794-4-RR (same clone as 84794-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84794-4-RR (gp130/IL6ST antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84794-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84794-4-RR

    Affinity and Kinetic Characterization of 84794-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84794-4-RR against Mouse gp130/IL6ST were performed. The affinity constant is 89.7 pM.

Geprüfte Anwendungen

Produktinformation

84794-4-PBS bindet in WB, Indirect ELISA gp130/IL6ST und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen gp130/IL6ST fusion protein Eg1631
Vollständiger Name interleukin 6 signal transducer
Berechnetes Molekulargewicht102kDa, 917aa
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerNM_010560.3
Gene symbol Il6st
Gene ID (NCBI) 16195
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GP130, also known as IL6ST, is a transmembrane protein that serves as a shared signal-transducing subunit for a variety of cytokines(PMID: 39414364), including interleukin-6 (IL-6), IL-11, IL-27, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC)/CLC factor 1 (CLCF-1), and neuropoietin (PMID: 24099136). This protein is highly conserved among vertebrates and plays a crucial role in mediating interactions between a wide range of immune and non-immune cells. GP130 was originally discovered in 1978 and was successfully cloned and expressed in 1990, leading to a deeper understanding of cytokine signaling pathways (PMID: 308233).