nectin 4 Rekombinanter Antikörper
nectin 4 Rekombinant Antikörper für Cytometric bead array, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
Cytometric bead array, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
240009G5
Kat-Nr. : 83223-2-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
83223-2-PBS bindet in Cytometric bead array, Indirect ELISA nectin 4 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | nectin 4 fusion protein Eg0415 |
| Vollständiger Name | poliovirus receptor-related 4 |
| Berechnetes Molekulargewicht | 510 aa, 55 kDa |
| GenBank-Zugangsnummer | BC010423 |
| Gene symbol | Nectin-4 |
| Gene ID (NCBI) | 81607 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Nectin-4, also known as PVRL4, is a type-I transmembrane glycoprotein that belongs to the nectin subfamily of immunoglobulin-like adhesion molecules that participate in Ca(2+)-independent cell-cell adhesion (PMID: 18703497). The extracellular domain of Nectin-4, which contains three immunoglobulin-like domains (V and two C2-type domains, VCC), can be proteolytically cleaved to release a soluble form. Nectin-4 interacts with afadin via its carboxyl-terminal cytoplasmic sequence and trans-interacts with nectin-1/PRR1 through V domain interaction (PMID: 11544254). It acts as a receptor for measles virus (PMID: 22048310). Nectin-4 is overexpressed in multiple human malignancies and the aberrant expression is correlated with cancer progression and poor prognostic (PMID: 35131876). Nectin-4 can be detected as a soluble form of 43 kDa and a transmembrane form of 66 kDa (PMID: 15784625).
