p120 Catenin Monoklonaler Antikörper

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• KD/KO Validated

p120 Catenin Monoklonal Antikörper für IF

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IF

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

2F7H8

Kat-Nr. : CL594-66208

Synonyme

CAS, Catenin delta 1, CTNND, CTNND1, KIAA0384, p120, p120 catenin, p120(cas), p120(ctn), P120CAS, P120CTN

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Galerie der Validierungsdaten

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  IF Staining of human breast cancer using CL594-66208

  Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using the CoraLite®594-conjugated version of this antibody, CL594-66208 (p120 Catenin antibody), at dilution of 1:100.

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  IF Staining of human breast cancer using CL594-66208

  Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using the CoraLite®594-conjugated version of this antibody, CL594-66208 (p120 Catenin antibody), at dilution of 1:100.

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  IF Staining of MCF-7 using CL594-66208

  Immunofluorescent analysis of (-20°C Ethanol) fixed MCF-7 cells using CL594-66208 (p120 Catenin antibody) at dilution of 1:100.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF: MCF-7-Zellen, humanes Mammakarzinomgewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF): IF : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

CL594-66208 bindet in IF p120 Catenin und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG2b
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: p120 Catenin fusion protein Ag2824
• Vollständiger Name: catenin (cadherin-associated protein), delta 1
• Berechnetes Molekulargewicht: 948 aa, 105 kDa
• Beobachtetes Molekulargewicht: 90-120 kDa
• GenBank-Zugangsnummer: BC010501
• Gene symbol: CTNND1
• Gene ID (NCBI): 1500
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins (PMID: 9653641). p120 catenin, also called p120 ctn or catenin delta-1, regulates cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins. p120 catenin is a tyrosine kinase substrate implicated in cell transformation by SRC, as well as in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor, and the CSF1 receptor. Different expression patterns of p120 catenin in lobular and ductal carcinomas of breast have been reported: membrane stain for ductal carcinoma and cytoplasmic stain for lobular carcinoma (PMID: 24966968). Different isoforms of p120 catenin are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons (PMID: 19150613).