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phospho(403/404)-TDP43 Polyklonaler Antikörper

phospho(403/404)-TDP43 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22310-1-AP

Synonyme

ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43

Geprüfte Anwendungen

Produktinformation

22310-1-AP bindet in ELISA phospho(403/404)-TDP43 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name TAR DNA binding protein
Berechnetes Molekulargewicht 43 kDa
GenBank-ZugangsnummerNM_007375
Gene symbol TDP-43
Gene ID (NCBI) 23435
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U).10782-2-AP is a rabbit polyclonal antibody recognizing the cleavage product of 20-30 kDa in addition to the native and phosphorylated forms of TDP-43. Immunohistochemical analyses of TDP-43 using this antibody detect both normal diffuse nuclear staining and insoluble inclusions in pathologic tissues. A variety of TDP-43-positive pathological inclusions have been found in FTLD-U (now referred to as FTLD-TDP), including neuronal cytoplasmic inclusions (NCIs), dystrophic neurites (DNs), neuronal intra-nuclear inclusions (NIIs), and glial cytoplasmic inclusions (GCIs).