uPAR/CD87 Rekombinanter Antikörper

uPAR/CD87 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242976A9

Kat-Nr. : 98424-3-PBS

Synonyme

CD87, Plaur, uPAR, U-PAR, Urokinase plasminogen activator surface receptor

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  FC experiment of Transfected HEK-293T using 98424-3-RR (same clone as 98424-3-PBS)

  1x10^6 HEK-293T cells or uPAR/CD87 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse uPAR/CD87 Rabbit RecAb (98424-3-RR, Clone: 242976A9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98424-3-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98424-3-RR (same clone as 98424-3-PBS)

  1x10^6 HEK-293T cells or uPAR/CD87 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse uPAR/CD87 Rabbit RecAb (98424-3-RR, Clone: 242976A9) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98424-3-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98424-3-PBS bindet in FC uPAR/CD87 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: uPAR/CD87 fusion protein Eg3156
• Vollständiger Name: plasminogen activator, urokinase receptor
• Berechnetes Molekulargewicht: 35 kDa
• GenBank-Zugangsnummer: NM_011113.4
• Gene symbol: Plaur
• Gene ID (NCBI): 18793
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)