uPAR/CD87 Rekombinanter Antikörper

uPAR/CD87 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Biotin

CloneNo.

240366G10

Kat-Nr. : Biotin-FcA98048

Synonyme

PLAUR, 240366G10, CD87, MO3, U PAR

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  FC experiment of U-937 using Biotin-FcA98048

  1x10^6 PMA-treated U-937 cells were surface stained with 0.25 ug Biotin Anti-Human uPAR/CD87 Rabbit RecAb (Biotin-FcA98048, Clone: 240366G10) (red) or 0.25 ug FcZero-rAb™ Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9) (blue). 1x10^6 untreated U-937 cells were surface stained with 0.25 ug Biotin Anti-Human uPAR/CD87 Rabbit RecAb (Biotin-FcA98048, Clone: 240366G10) (black, dashed). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: PMA treated U-937 cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

Biotin-FcA98048 bindet in FC uPAR/CD87 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: uPAR/CD87 fusion protein Eg0901
• Vollständiger Name: PLAUR
• Berechnetes Molekulargewicht: 37 kDa
• GenBank-Zugangsnummer: NM_002659.4
• Gene symbol: uPAR
• Gene ID (NCBI): 5329
• Konjugation: Biotin
• Excitation/Emission maxima wavelengths: -
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)