uPAR/CD87 Rekombinanter Antikörper

uPAR/CD87 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

240366G10

Kat-Nr. : CL488-98048

Synonyme

PLAUR, UPAR, U PAR, MO3, CD87

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  FC experiment of U-937 using CL488-98048

  1x10^6 PMA treated U-937 cells were surface stained with 5 ul CoraLite® Plus 488 Anti-Human uPAR/CD87 Rabbit Recombinant Antibody (CL488-98048, Clone:240366G10) (red), or Isotype Control (blue). 1x10^6 untreated U-937 cells were surface stained with 5 ul CoraLite® Plus 488 Anti-Human uPAR/CD87 Rabbit Recombinant Antibody (CL488-98048, Clone:240366G10) (black, dashed). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: PMA treated U-937 cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

CL488-98048 bindet in FC uPAR/CD87 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Fusionsprotein
• Vollständiger Name: PLAUR
• Berechnetes Molekulargewicht: 37 kDa
• GenBank-Zugangsnummer: NM_002659.4
• Gene symbol: uPAR
• Gene ID (NCBI): 5329
• Konjugation: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)