Anticorps Recombinant de lapin anti-ABCB10

ABCB10 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251920E7

N° de cat : 86853-1-PBS

Synonymes

ABC transporter 10 protein, ABC-me protein, ABC-mitochondrial erythroid protein, ATP-binding cassette sub-family B member 10, mitochondrial, ATP-binding cassette transporter 10

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Galerie de données de validation

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  WB analysis using 86853-1-RR (same clone as 86853-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86853-1-RR (ABCB10 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86853-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86853-1-PBS cible ABCB10 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ABCB10 Protéine recombinante Ag6203
• Nom complet: ATP-binding cassette, sub-family B (MDR/TAP), member 10
• Masse moléculaire calculée: 79 kDa
• Poids moléculaire observé: 60 kDa
• Numéro d’acquisition GenBank: BC064930
• Symbole du gène: ABCB10
• Identification du gène (NCBI): 23456
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ABCB10 (also known as ABC-me or M-ABC2) is an inner-mitochondrial-membrane ATP-binding cassette transporter that forms homodimers with its nucleotide-binding domain facing the matrix. ABCB10 is now recognized as a multifunctional protein that couples mitochondrial export activity to cellular antioxidant defence. During red-cell development it stabilises the iron importer mitoferrin-1 (Mfrn1), thereby sustaining heme synthesis, whereas in cardiac and other non-erythroid tissues it attenuates oxidative damage by limiting mitochondrial ROS accumulation. PMID: 22884976

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