Anticorps Polyclonal de lapin anti-ABCC5

ABCC5 Polyclonal Antibody for IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

N° de cat : 19503-1-AP

Synonymes

ABC33, ABCC5, MOAT C, MOATC, MRP5, pABC11, SMRP



Applications testées

Résultats positifs en IHCtissu de tumeur ovarienne humain, tissu de cancer du pancréas humain
il est suggéré de démasquer l'antigène avec un tampon de TE buffer pH 9.0; (*) À défaut, 'le démasquage de l'antigène peut être 'effectué avec un tampon citrate pH 6,0.

Dilution recommandée

ApplicationDilution
Immunohistochimie (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

19503-1-AP cible ABCC5 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Réactivité citéeHumain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Masse moléculaire calculée 161 kDa
Numéro d’acquisition GenBankNM_005688
Symbole du gène ABCC5
Identification du gène (NCBI) 10057
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).

Protocole

Product Specific Protocols
IHC protocol for ABCC5 antibody 19503-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Front Oncol

Screening of co-pathogenic genes of non-alcoholic fatty liver disease and hepatocellular carcinoma

Authors - Ting Chen
humanIHC

Front Genet

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma.

Authors - Xin Zhou
humanWB

Oncol Lett

Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Authors - Hao Wang

Avis

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


FH

Yu Siong (Verified Customer) (03-01-2019)

Multiple bands appeared, non-specific binding, bands did not appear at exact molecular size.

  • Applications: Western Blot,
  • Primary Antibody Dilution: 1:200
  • Cell Tissue Type: Porcine brain endothelial cells
ABCC5 Antibody Western Blot, validation (1:200 dilution) in Porcine brain endothelial cells (Cat no:19503-1-AP)