Anticorps Monoclonal anti-ABCC5

ABCC5 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2H10F11

N° de cat : 67955-1-PBS

Synonymes

ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP

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Galerie de données de validation

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  WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

  Boiled and unboiled HepG2 lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

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  WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67955-1-PBS cible ABCC5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ABCC5 Protéine recombinante Ag31674
• Nom complet: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
• Masse moléculaire calculée: 161 kDa
• Poids moléculaire observé: 180-200kDa
• Numéro d’acquisition GenBank: NM_005688
• Symbole du gène: ABCC5
• Identification du gène (NCBI): 10057
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).

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