Anticorps Recombinant de lapin anti-ABR

ABR Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241121G1

N° de cat : 84011-6-PBS

Synonymes

MDB, active BCR related gene, 241121G1

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Galerie de données de validation

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  WB analysis using 84011-6-RR (same clone as 84011-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84011-6-RR (ABR antibody) at dilution of 1:12000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84011-6-PBS in a different storage buffer formulation.

• 

  WB analysis using 84011-6-RR (same clone as 84011-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84011-6-RR (ABR antibody) at dilution of 1:12000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84011-6-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84011-6-RR

  Biolayer interferometry (BLl) kinetic assays of 84011-6-RR against Human ABR were performed. The affinity constant is 4.96 nM.

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Informations sur le produit

84011-6-PBS cible ABR dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ABR Protéine recombinante Ag29522
• Nom complet: active BCR-related gene
• Masse moléculaire calculée: 98 kDa
• Poids moléculaire observé: 97-100 kDa
• Numéro d’acquisition GenBank: NM_021962
• Symbole du gène: ABR
• Identification du gène (NCBI): 29
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ABR (Active breakpoint cluster region-related protein) is the only protein known in humans and mice to share high homology with BCR (68% amino acid identity). BCR(Breakpoint cluster region) gene was originally identified due to its involvement in a specific chromosomal translocation that causes the development of chronic myeloid leukemia and a subset of acute lymphoblastic leukemia. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. (PMID: 17116687, PMID: 37507586)

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