Anticorps Recombinant de lapin anti-ACE2

ACE2 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250137D6

N° de cat : 98508-1-PBS

Synonymes

ACE-related carboxypeptidase, Angiotensin-converting enzyme 2, EC:3.4.17.-, EC:3.4.17.23, Processed angiotensin-converting enzyme 2

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98508-1-RR (same clone as 98508-1-PBS)

  1x10^6 HEK-293T cells and ACE2-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse Ace2 Rabbit RecAb (98508-1-RR, Clone: 250137D6) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98508-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98508-1-RR (same clone as 98508-1-PBS)

  1x10^6 HEK-293T cells and ACE2-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse Ace2 Rabbit RecAb (98508-1-RR, Clone: 250137D6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98508-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98508-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98508-1-RR against Mouse ACE2 were performed. The affinity constant is 1.75 nM.

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Informations sur le produit

98508-1-PBS cible ACE2 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ACE2 Protéine recombinante Eg2834
• Nom complet: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
• Masse moléculaire calculée: 92 kDa
• Numéro d’acquisition GenBank: NM_001130513.1
• Symbole du gène: Ace2
• Identification du gène (NCBI): 70008
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455).

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