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Anticorps Polyclonal de lapin anti-ACVR1

ACVR1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11108-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of mouse kidney tissue using ACVR1 Polyclonal antibody (11108-1-AP)

    WB analysis of mouse kidney using 11108-1-AP (same clone as 11108-1-PBS)

    mouse kidney tissue were subjected to SDS PAGE followed by western blot with 11108-1-AP (ACVR1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11108-1-PBS in a different storage buffer formulation.

Informations sur le produit

11108-1-PBS cible ACVR1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène ACVR1 Protéine recombinante Ag1556
Nom complet activin A receptor, type I
Masse moléculaire calculée 509 aa, 57 kDa
Poids moléculaire observé57 kDa
Numéro d’acquisition GenBankBC033867
Symbole du gène ACVR1
Identification du gène (NCBI) 90
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).

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