Anticorps Polyclonal de lapin anti-ACVR1B

• Phare
• Validé par KD/KO

ACVR1B Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications(10)

N° de cat : 10086-1-AP

Synonymes

activin A receptor, type IB, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type-1B, Activin receptor-like kinase 4

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Galerie de données de validation

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  WB analysis using 10086-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 10086-1-AP (ACVR1B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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  WB analysis of HEK-293 using 10086-1-AP

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 10086-1-AP (ACVR1B Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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  WB analysis of HepG2 using 10086-1-AP

  DMSO treated HepG2 cells were subjected to SDS PAGE followed by western blot with 10086-1-AP (ACVR1B Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules HepG2, cellules HEK-293

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 2 publications below
• WB: See 9 publications below
• IHC: See 1 publications below
• IF: See 2 publications below

Informations sur le produit

10086-1-AP cible ACVR1B dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ACVR1B Protéine recombinante Ag0129
• Nom complet: activin A receptor, type IB
• Masse moléculaire calculée: 57 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC000254
• Symbole du gène: ACVR1B
• Identification du gène (NCBI): 91
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

ACVR1B (ALK4, activin A receptor type 1B) is a transforming growth factor-beta (TGF-beta) superfamily member (PMID: 37020544). A potential role for ACVR1B in regulating muscle mass is that it is part of the transforming growth factor b (TGFb) pathway regulating myostatin (PMID: 21063444).

Publications

Species	Application	Title
mouse	WB,IHC,IF	J Am Heart Assoc; Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy.; Authors - Qian Wang
mouse	WB,IF	Mol Cell Endocrinol; ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.; Authors - Li Ma
human	WB	Animals (Basel); Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B.; Authors - Xin Hu
human	WB	Reprod Biol Endocrinol; PMID: 29925391; Authors - Cheng Li
	WB	PeerJ; Overexpression of LINC00551 promotes autophagy-dependent ferroptosis of lung adenocarcinoma via upregulating DDIT4 by sponging miR-4328; Authors - Xiong Peng
rat	WB	J Toxicol Sci; Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway.; Authors - Zhenjian Lin

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