Anticorps Monoclonal anti-ACVRL1

ACVRL1 Monoclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2E11B10

N° de cat : 66857-1-PBS

Synonymes

2E11B10, Activin receptor like kinase 1, Activin receptor-like kinase 1, ACVRLK1, ALK 1

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Galerie de données de validation

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  WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

  HUVEC cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  WB analysis of JAR using 66857-1-Ig (same clone as 66857-1-PBS)

  JAR cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  WB analysis of human placenta using 66857-1-Ig (same clone as 66857-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse brain using 66857-1-Ig (same clone as 66857-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  WB analysis of Daudi using 66857-1-Ig (same clone as 66857-1-PBS)

  Daudi cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  WB analysis of Jurkat using 66857-1-Ig (same clone as 66857-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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  IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66857-1-PBS cible ACVRL1 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ACVRL1 Protéine recombinante Ag6446
• Nom complet: activin A receptor type II-like 1
• Masse moléculaire calculée: 56 kDa
• Poids moléculaire observé: 56 kDa, 63 kDa
• Numéro d’acquisition GenBank: BC042637
• Symbole du gène: ACVRL1
• Identification du gène (NCBI): 94
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.

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