Anticorps Recombinant de lapin anti-ADAR1

ADAR1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241595E8

N° de cat : 85009-1-PBS

Synonymes

ADAR, DRADA, Double-stranded RNA-specific adenosine deaminase, adenosine deaminase RNA specific, 241595E8

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Galerie de données de validation

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  WB analysis using 85009-1-RR (same clone as 85009-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85009-1-RR (ADAR1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85009-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85009-1-PBS cible ADAR1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ADAR1 Protéine recombinante Ag5609
• Nom complet: adenosine deaminase, RNA-specific
• Masse moléculaire calculée: 136 kDa
• Poids moléculaire observé: 110 kDa
• Numéro d’acquisition GenBank: BC038227
• Symbole du gène: ADAR1
• Identification du gène (NCBI): 103
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an IFN inducible ∼150 kDa protein and a constitutively expressed N-terminally truncated ∼110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).

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