Anticorps Polyclonal de lapin anti-AFF2

AFF2 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 25414-1-PBS

Synonymes

AF4/FMR2 family member 2, FMR2, FMR2P, FRAXE, MRX2

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Galerie de données de validation

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  WB analysis using 25414-1-AP (same clone as 25414-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25414-1-AP (AFF2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25414-1-PBS in a different storage buffer formulation.

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  IP experiment of SH-SY5Y using 25414-1-AP (same clone as 25414-1-PBS)

  IP result of anti-AFF2 (IP:25414-1-AP, 4ug; Detection:25414-1-AP 1:600) with SH-SY5Y cells lysate 1720 ug. This data was developed using the same antibody clone with 25414-1-PBS in a different storage buffer formulation.

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Informations sur le produit

25414-1-PBS cible AFF2 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: AFF2 Protéine recombinante Ag22225
• Nom complet: AF4/FMR2 family, member 2
• Masse moléculaire calculée: 1311 aa, 145 kDa
• Poids moléculaire observé: 145 kDa
• Numéro d’acquisition GenBank: BC132683
• Symbole du gène: AFF2
• Identification du gène (NCBI): 2334
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

AFF2 (OMIM* 300806) (also known as FMR2 gene), which encodes AF4/FMR2 family member 2, is a transcriptional factor and RNA-binding protein that plays an important role in transcriptional regulation, RNA splicing, mRNA processing, and nuclear speckle organization . AFF2 is highly conserved and abundantly expressed in human brain, being essential for brain development. Homozygous AFF2 knock-out mice showed abnormal central nervous system synaptic transmission, abnormal excitatory postsynaptic potential, and premature death (PMID: 35431806).

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