Anticorps Monoclonal anti-AGTR1

AGTR1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2C5G11

N° de cat : 66415-1-PBS

Synonymes

Angiotensin II type-1 receptor, Angiotensin II type 1 receptor, AGTR1B, AGTR1A, AG2S

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Galerie de données de validation

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  WB analysis of pig heart using 66415-1-Ig (same clone as 66415-1-PBS)

  pig heart tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat heart using 66415-1-Ig (same clone as 66415-1-PBS)

  rat heart tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

• 

  WB analysis of pig skeletal muscle using 66415-1-Ig (same clone as 66415-1-PBS)

  pig skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66415-1-PBS cible AGTR1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: AGTR1 Protéine recombinante Ag14461
• Nom complet: angiotensin II receptor, type 1
• Masse moléculaire calculée: 359 aa, 41 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC022447
• Symbole du gène: AGTR1
• Identification du gène (NCBI): 185
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).

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