Anticorps Monoclonal anti-ALK

ALK Monoclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

7G9E3

N° de cat : 60321-1-PBS

Synonymes

ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, TFG/ALK

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Galerie de données de validation

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  IHC staining of human lymphoma using 60321-1-Ig (same clone as 60321-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human anaplastic large cell lymphoma (ALCL) tissue slide using 60321-1-Ig (ALK antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60321-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lymphoma using 60321-1-Ig (same clone as 60321-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human anaplastic large cell lymphoma (ALCL) tissue slide using 60321-1-Ig (ALK/CD246 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60321-1-PBS in a different storage buffer formulation.

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Informations sur le produit

60321-1-PBS cible ALK dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ALK Protéine recombinante Ag21493
• Nom complet: anaplastic lymphoma receptor tyrosine kinase
• Masse moléculaire calculée: 1620 aa, 176 kDa
• Numéro d’acquisition GenBank: NM_004304
• Symbole du gène: ALK
• Identification du gène (NCBI): 238
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).

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