Anticorps Polyclonal de lapin anti-ALKBH2
ALKBH2 Polyclonal Antibody for WB, Indirect ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain
Applications
WB, Indirect ELISA
Conjugaison
Non conjugué
N° de cat : 17809-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
17809-1-PBS cible ALKBH2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Polyclonal |
| Type | Anticorps |
| Immunogène | ALKBH2 Protéine recombinante Ag12108 |
| Nom complet | alkB, alkylation repair homolog 2 (E. coli) |
| Masse moléculaire calculée | 261 aa, 29 kDa |
| Poids moléculaire observé | 30-35 kDa |
| Numéro d’acquisition GenBank | BC070489 |
| Symbole du gène | ALKBH2 |
| Identification du gène (NCBI) | 121642 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité contre l'antigène |
| Tampon de stockage | PBS only |
| Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
Escherichia coli AlkB is a DNA repair enzyme that represents the founding member of the AlkB family of non-heme iron-dependent dioxygenases. The human genome encodes nine AlkB homologs termed AlkB homolog 1 through 8 (ALKBH1 through 8) plus a ninth member termed fat mass and obesity associated (FTO). Bacterial AlkB as well as human ALKBH2 and ALKBH3 catalyze the direct reversal of DNA methylation damage through a distinct oxidative demethylation reaction. Importantly, ALKBH2 has been shown to play a role in DNA alkylation damage repair in human, mouse and plant cells. Full-length ALKBH2 has a molecular weight of about 30kDa and ALKBH2 variant encoded by an alternatively spliced transcript with a frameshift deletion of the C-terminal dioxygenase domain has a molecular weight of about 25kDa (PMID:22079122).
