Anticorps Polyclonal de lapin anti-ANAPC11

ANAPC11 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15065-1-PBS

Synonymes

APC11, ANAPC 11, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p

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Galerie de données de validation

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  WB analysis using 15065-1-AP (same clone as 15065-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15065-1-AP (ANAPC11 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15065-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15065-1-PBS cible ANAPC11 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ANAPC11 Protéine recombinante Ag7069
• Nom complet: anaphase promoting complex subunit 11
• Masse moléculaire calculée: 21 kDa, 10 kDa
• Poids moléculaire observé: 21 kDa
• Numéro d’acquisition GenBank: BC000607
• Symbole du gène: APC11
• Identification du gène (NCBI): 51529
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Anaphase-promoting complex subunit 11 (ANAPC11) is a core catalytic subunit of the anaphase-promoting complex/cyclosome (APC/C). ANAPC11 is involved in the ubiquitination and degradation of key cell cycle regulators, including cyclin B and securin, facilitating the transition from metaphase to anaphase during cell division (PMID: 11739784; 18485873). ANAPC11 also mediates the ubiquitination and degradation of the Forkhead transcription factor FOXO3, promoting cell proliferation and lymph node metastasis in urothelial bladder cancer (PMID: 37573356).

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