Anticorps Recombinant de lapin anti-APC

APC Recombinant Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242726D4

N° de cat : 85372-1-PBS

Synonymes

adenomatous polyposis coli, Adenomatous polyposis coli protein, DP2.5

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Galerie de données de validation

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  IHC staining of human colon using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 85372-1-RR (same clone as 85372-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 85372-1-RR (APC antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85372-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85372-1-PBS cible APC dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: adenomatous polyposis coli
• Masse moléculaire calculée: 312 kDa
• Numéro d’acquisition GenBank: NM_000038
• Symbole du gène: APC
• Identification du gène (NCBI): 324
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

APC, also named as DP2.5, belongs to the adenomatous polyposis coli (APC) family. APC is a tumor suppressor that regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division, and associates with other proteins involved in cell attachment and signaling. APC promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. It plays a critical role in several cellular processes. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. APC activity is correlated with its phosphorylation state. Defects in APC are a cause of familial adenomatous polyposis (FAP) which includes also Gardner syndrome (GS). Defects in APC are a cause of hereditary desmoid disease (HDD) which also known as familial infiltrative fibromatosis (FIF). Defects in APC are a cause of medulloblastoma (MDB) which is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) which also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1).

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