Anticorps Polyclonal de lapin anti-APP

APP Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(4)

N° de cat : 10524-1-AP

Synonymes

amyloid precursor protein, Alzheimer disease amyloid protein, Alzheimer disease amyloid A4 protein homolog, AD1, AB42

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Galerie de données de validation

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Applications publiées

• WB: See 3 publications below
• IF: See 1 publications below

Informations sur le produit

10524-1-AP cible APP dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: APP Protéine recombinante Ag0769
• Nom complet: amyloid beta (A4) precursor protein
• Masse moléculaire calculée: 87 kDa
• Numéro d’acquisition GenBank: BC004369
• Symbole du gène: APP
• Identification du gène (NCBI): 351
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta.

Publications

Species	Application	Title
mouse	WB	Neurobiol Aging; Beta amyloid-induced upregulation of death receptor 6 accelerates the toxic effect of N-terminal fragment of amyloid precursor protein.; Authors - Yuxia Xu
rat	WB	Int J Biol Macromol; Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer's disease.; Authors - Yan Zhang
human	WB	Neurotoxicology; Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway; Authors - Guoqing Wang
human	IF	bioRxiv; Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease; Authors - Xiuli Dan

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