Anticorps Recombinant de lapin anti-GRAF

GRAF Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

240086A11

N° de cat : 83206-1-PBS

Synonymes

ARHGAP26, 240086A11, GRAF1, KIAA0621, Oligophrenin 1 like protein

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Galerie de données de validation

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  WB analysis using 83206-1-RR (same clone as 83206-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83206-1-RR (GRAF antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83206-1-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP00157-1

  Cytometric bead array standard curve of MP00157-1, ARHGAP26 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83206-2-PBS. Detection antibody: 83206-1-PBS. Standard: Ag12008. Range: 0.625-20 ng/mL.

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Informations sur le produit

83206-1-PBS cible GRAF dans les applications de WB, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: GRAF Protéine recombinante Ag12008
• Nom complet: Rho GTPase activating protein 26
• Masse moléculaire calculée: 759 aa, 86 kDa
• Poids moléculaire observé: 92-100 kDa
• Numéro d’acquisition GenBank: BC068555
• Symbole du gène: ARHGAP26
• Identification du gène (NCBI): 23092
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GTPase Regulator Associated with Focal Adhesion Kinase (GRAF), also known as Rho GTPase activating protein 26 (ARHGAP26) , is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. GRAF enhances the hydrolysis of GTPases and converts GTPases from an active form to an inactive form, thereby inhibiting signaling transduction. Deletion and mutation of ARHGAP26 can lead to promyelocytic leukemia, suggesting tumor suppressive activity of ARHGAP26. ARHGAP26 was downregulated in glioblastoma and associated with cell proliferation and migration (PMID: 10908648, PMID: 17611651, PMID: 31004081).

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