Anticorps Recombinant de lapin anti-ARHGEF11

ARHGEF11 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241427G2

N° de cat : 84149-4-PBS

Synonymes

241427G2, GTRAP48, KIAA0380, PDZ RHOGEF

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Galerie de données de validation

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  WB analysis using 84149-4-RR (same clone as 84149-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84149-4-RR (ARHGEF11 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84149-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84149-4-PBS

  Biolayer interferometry (BLl) kinetic assay of 84149-4-PBS against Human ARHGEF11 was performed. The affinity constant is 0.707 nM.

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  Affinity and Kinetic Characterization of 84149-4-RR

  Biolayer interferometry (BLl) kinetic assays of 84149-4-RR against Human ARHGEF11 were performed. The affinity constant is 0.742 nM.

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Informations sur le produit

84149-4-PBS cible ARHGEF11 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ARHGEF11 Protéine recombinante Ag33104
• Nom complet: Rho guanine nucleotide exchange factor (GEF) 11
• Masse moléculaire calculée: 168 kDa
• Poids moléculaire observé: 220 kDa
• Symbole du gène: ARHGEF11
• Identification du gène (NCBI): 9826
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ARHGEF11 (Rho guanine nucleotide exchange factor 11) is a specific guanine nucleotide exchange factor (GEF) for RhoA, which is a critical regulator of actin cytoskeleton dynamics and organization of dendritic spines and inhibitor of spine maintenance (PMID: 28036092). ARHGEF11 has been proven to promote tumor metastasis in glioblastoma and ovarian carcinoma (PMID: 33122451).

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