Anticorps Monoclonal anti-ASGR1

• Phare
• Validé par KD/KO

ASGR1 Monoclonal Antibody for IF-P

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, porc, rat, souris

Applications

IF-P

Conjugaison

PE Fluorescent Dye

CloneNo.

1G5F5

N° de cat : PE-66692

Synonymes

asialoglycoprotein receptor 1, HL-1, Asgpr1, ASGP-R 1, ASGPR 1

---

Galerie de données de validation

• 

  IF Staining of rat liver using PE-66692

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded rat liver tissue using PE ASGR1 antibody (PE-66692, Clone: 1G5F5 ) at dilution of 1:100. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

---

Applications testées

• Résultats positifs en IF-P: tissu hépatique de rat,

Dilution recommandée

• Immunofluorescence (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

PE-66692 cible ASGR1 dans les applications de IF-P et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ASGR1 Protéine recombinante Ag2310
• Nom complet: asialoglycoprotein receptor 1
• Masse moléculaire calculée: 291 aa, 33 kDa
• Poids moléculaire observé: 42-46 kDa
• Numéro d’acquisition GenBank: BC032130
• Symbole du gène: ASGR1
• Identification du gène (NCBI): 432
• Conjugaison: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. 20ul contiennent 0,1% de BSA.

Informations générales

Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.

{{ptg:RelatedPrimaryAntibodies}}