Anticorps Monoclonal anti-ASGR2

ASGR2 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2A5C12

N° de cat : 66831-1-PBS

Synonymes

ASGP R, ASGP R 2, ASGPR 2, ASGR2, asialoglycoprotein receptor 2, CLEC4H2, Hepatic lectin H2, HL 2, Hs.1259, L H2

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Galerie de données de validation

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  WB analysis of SMMC-7721 using 66831-1-Ig (same clone as 66831-1-PBS)

  SMMC-7721 cells were subjected to SDS PAGE followed by western blot with 66831-1-Ig (ASGR2 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66831-1-PBS in a different storage buffer formulation.

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  WB analysis of HSC-T6 using 66831-1-Ig (same clone as 66831-1-PBS)

  HSC-T6 cells were subjected to SDS PAGE followed by western blot with 66831-1-Ig (ASGR2 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66831-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66831-1-PBS cible ASGR2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ASGR2 Protéine recombinante Ag2037
• Nom complet: asialoglycoprotein receptor 2
• Masse moléculaire calculée: 39 kDa
• Poids moléculaire observé: 36 kDa
• Numéro d’acquisition GenBank: BC017251
• Symbole du gène: ASGR2
• Identification du gène (NCBI): 433
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.

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