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Anticorps Monoclonal anti-ASL

ASL Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1G9H3

N° de cat : 67692-1-PBS

Synonymes

argininosuccinate lyase, Arginosuccinase, ASAL, ASL

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using ASL Monoclonal antibody (67692-1-Ig)

    WB analysis using 67692-1-Ig (same clone as 67692-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67692-1-Ig (ASL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67692-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of LNCaP cells using ASL Monoclonal antibody (67692-1-Ig)

    WB analysis of LNCaP using 67692-1-Ig (same clone as 67692-1-PBS)

    LNCaP cells were subjected to SDS PAGE followed by western blot with 67692-1-Ig (ASL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67692-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of K-562 cells using ASL Monoclonal antibody (67692-1-Ig)

    WB analysis of K-562 using 67692-1-Ig (same clone as 67692-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 67692-1-Ig (ASL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67692-1-PBS in a different storage buffer formulation.

Informations sur le produit

67692-1-PBS cible ASL dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

Réactivité Humain, porc, rat, souris
Hôte / Isotype Mouse / IgG2b
Clonalité Monoclonal
Type Anticorps
Immunogène ASL Protéine recombinante Ag30517
Nom complet argininosuccinate lyase
Masse moléculaire calculée 55 kDa
Poids moléculaire observé50 kDa
Numéro d’acquisition GenBankBC008195
Symbole du gène ASL
Identification du gène (NCBI) 435
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Argininosuccinate lyase (ASL), one of the significant UC enzymes, catalyzes argininosuccinate cleavage to generate arginine and fumarate. Arginine is then catalyzed by arginase to ornithine and polyamines, which are found to promote cancer cell proliferation and growth. Importantly, ASL ectopic expression is closely associated with poor prognosis of colorectal cancer, hepatocellular. ASL is a member of the aspartase/fumarase superfamily. Enzymes of this superfamily share similar tetrameric structure and active site, though the sequence identities between different members are quite low (less than 20%). Members of this superfamily have been recognised as drug targets for microbial infections. ASL is a 464-amino-acid enzyme with a molecular mass of 49.7 kDa. (PMID: 22386318 PMID: 31018905)

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