Anticorps Polyclonal de lapin anti-ASXL2

ASXL2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27229-1-PBS

Synonymes

Additional sex combs-like protein 2, ASXH2, KIAA1685

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Galerie de données de validation

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  WB analysis using 27229-1-AP (same clone as 27229-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27229-1-AP (ASXL2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27229-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27229-1-PBS cible ASXL2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ASXL2 Protéine recombinante Ag24402
• Nom complet: additional sex combs like 2 (Drosophila)
• Masse moléculaire calculée: 154 kDa
• Poids moléculaire observé: 154-230 kDa
• Numéro d’acquisition GenBank: BC042999
• Symbole du gène: ASXL2
• Identification du gène (NCBI): 55252
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ASXL2 is an epigenetic regulator associated with various tumors including colorectal cancer, breast cancer, and myeloid leukemia. ASXL1, ASXL2 and ASXL3 are human homologs of Drosophila Asx (Additional sex combs) and function as epigenetic regulators through recruitment of Polycomb group repressor complexes (PRC) and Trithorax group activator complexes. ASXL proteins can interact with BAP1, NCOA1, EZH2, WTIP and nuclear receptors, which suggests diverse functions of ASXL family members in epigenetic and transcriptional regulation. (PMID: 30093396, PMID: 34692512)

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