Anticorps Polyclonal de lapin anti-ATF7IP

• Phare
• Validé par KD/KO

ATF7IP Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 14699-1-PBS

Synonymes

ATF-interacting protein, ATFa-associated modulator, ATF7-interacting protein, ATF7, ATF

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Galerie de données de validation

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  IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary tumor using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

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  IHC staining of human stomach cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

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Informations sur le produit

14699-1-PBS cible ATF7IP dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ATF7IP Protéine recombinante Ag6341
• Nom complet: activating transcription factor 7 interacting protein
• Masse moléculaire calculée: 137 kDa
• Numéro d’acquisition GenBank: BC063855
• Symbole du gène: ATF7IP
• Identification du gène (NCBI): 55729
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ATF7IP (Activating Transcription Factor 7 Interacting Protein), also known as MCAF1 (MBD1-containing chromatin-associated factor 1), is a multifunctional scaffold protein that plays a pivotal role in epigenetic regulation and transcriptional control. Functionally, ATF7IP acts as an adaptor that recruits the histone methyltransferase SETDB1 to specific genomic loci, facilitating the deposition of the heterochromatin mark H3K9me3 and silencing target genes, including retrotransposons such as LINE1. This activity is essential for maintaining genomic stability by suppressing transposable element mobilization and preventing DNA damage.

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