Anticorps Polyclonal de lapin anti-ATXN1

ATXN1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27265-1-PBS

Synonymes

ataxin 1, ataxin1, Ataxin-1, ATX1, ATXN 1

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Galerie de données de validation

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  WB analysis using 27265-1-AP (same clone as 27265-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27265-1-AP (ATXN1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27265-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27265-1-PBS cible ATXN1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ATXN1 Protéine recombinante Ag26099
• Nom complet: ataxin 1
• Masse moléculaire calculée: 87 kDa
• Poids moléculaire observé: 100 kDa
• Numéro d’acquisition GenBank: NM_000332
• Symbole du gène: ATXN1
• Identification du gène (NCBI): 6310
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Ataxin-1 (ATXN1) is a protein involved in transcriptional regulation and RNA binding. It is a transcriptional repressor that interacts with multiple transcription factors and is associated with large protein complexes. ATXN1 is also involved in the regulation of alternative splicing, as demonstrated by its ability to regulate the splicing of several minigenes. The protein is crucial for normal cerebellar function and is implicated in the pathogenesis of spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder caused by the expansion of a polyglutamine tract in ATXN1 (PMID: 21475249; 20628574).

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