Anticorps Monoclonal anti-AXIN2

AXIN2 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1A11A4

N° de cat : 67458-1-PBS

Synonymes

Axin-2, Axil, axin 2, Axin like protein, Axin-like protein

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Galerie de données de validation

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  WB analysis using 67458-1-Ig (same clone as 67458-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67458-1-Ig (AXIN2 antibody) at dilution of 1:4800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67458-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67458-1-PBS cible AXIN2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: AXIN2 Protéine recombinante Ag29291
• Nom complet: axin 2
• Masse moléculaire calculée: 843 aa, 94 kDa
• Poids moléculaire observé: 100 kDa
• Numéro d’acquisition GenBank: BC006295
• Symbole du gène: AXIN2
• Identification du gène (NCBI): 8313
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidomain scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutation is involved in colorectal cancer.

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