Anticorps Recombinant de lapin anti-Angiotensinogen/AGT

Angiotensinogen/AGT Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251419A5

N° de cat : 86729-1-PBS

Synonymes

AGT, Angiotensinogen, Serpin A8, SERPINA8, Alpha 1 antiproteinase

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Galerie de données de validation

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  WB analysis of human plasma using 86729-1-RR (same clone as 86729-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 86729-1-RR (Angiotensinogen/AGT antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86729-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HepG2 using 86729-1-RR (same clone as 86729-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 86729-1-RR (Angiotensinogen/AGT antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86729-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86729-1-PBS cible Angiotensinogen/AGT dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Angiotensinogen/AGT Protéine recombinante Eg3099
• Nom complet: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
• Masse moléculaire calculée: 52 kDa
• Poids moléculaire observé: 53 kDa
• Numéro d’acquisition GenBank: NM_000029.4
• Symbole du gène: AGT
• Identification du gène (NCBI): 183
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene also have been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

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