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  • Validé par KD/KO

Anticorps Monoclonal anti-Arginase-1

Arginase-1 Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA, Sample test

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, Lapin, porc, rat, souris

Applications

WB, IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA, Sample test

Conjugaison

Non conjugué

CloneNo.

5D6D12

N° de cat : 66129-1-PBS

Synonymes

ARG1, Arginase 1, liver Arginase, 5D6D12, ARG 1



Informations sur le produit

66129-1-PBS cible Arginase-1 dans les applications de WB, IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA, Sample test et montre une réactivité avec des échantillons Humain, Lapin, porc, rat, souris

Réactivité Humain, Lapin, porc, rat, souris
Hôte / Isotype Mouse / IgG1
Clonalité Monoclonal
Type Anticorps
Immunogène Arginase-1 Protéine recombinante Ag8810
Nom complet arginase, liver
Masse moléculaire calculée236aa,25 kDa; 322aa,35 kDa
Poids moléculaire observé 36 kDa
Numéro d’acquisition GenBankBC005321
Symbole du gène Arginase-1
Identification du gène (NCBI) 383
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine G
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins (PMID: 20071539, PMID:12098359). It can exsit as a homotrimer and it has 3 isoforms produced by alternative splicing (PMID:16141327). Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control (PMID:27117406). Before stroke, ARG1 mainly expressed in neurons in a normal brain (PMID: 23311438). The expression of ARG1 increases in microglia/macrophages and astrocytes early after CNS injuries. ARG1 has been regarded as a marker for beneficial microglia/macrophages and possesses antiinflammatory and tissue repair properties under various pathological conditions (PMID: 26538310, PMID: 31619589).

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