- Phare
- Validé par KD/KO
Anticorps Monoclonal anti-Arginase-1
Arginase-1 Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA, Sample test
Hôte / Isotype
Mouse / IgG1
Réactivité testée
Humain, Lapin, porc, rat, souris
Applications
WB, IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA, Sample test
Conjugaison
Non conjugué
CloneNo.
5D6D12
N° de cat : 66129-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
66129-1-PBS cible Arginase-1 dans les applications de WB, IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA, Sample test et montre une réactivité avec des échantillons Humain, Lapin, porc, rat, souris
Réactivité | Humain, Lapin, porc, rat, souris |
Hôte / Isotype | Mouse / IgG1 |
Clonalité | Monoclonal |
Type | Anticorps |
Immunogène | Arginase-1 Protéine recombinante Ag8810 |
Nom complet | arginase, liver |
Masse moléculaire calculée | 236aa,25 kDa; 322aa,35 kDa |
Poids moléculaire observé | 36 kDa |
Numéro d’acquisition GenBank | BC005321 |
Symbole du gène | Arginase-1 |
Identification du gène (NCBI) | 383 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par protéine G |
Tampon de stockage | PBS only |
Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins (PMID: 20071539, PMID:12098359). It can exsit as a homotrimer and it has 3 isoforms produced by alternative splicing (PMID:16141327). Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control (PMID:27117406). Before stroke, ARG1 mainly expressed in neurons in a normal brain (PMID: 23311438). The expression of ARG1 increases in microglia/macrophages and astrocytes early after CNS injuries. ARG1 has been regarded as a marker for beneficial microglia/macrophages and possesses antiinflammatory and tissue repair properties under various pathological conditions (PMID: 26538310, PMID: 31619589).