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Anticorps Recombinant de lapin anti-BAG2

BAG2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242717G4

N° de cat : 85063-4-PBS

Synonymes

242717G4, BAG-2, KIAA0576

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using BAG2 Recombinant antibody (85063-4-RR)

    WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85063-4-RR (BAG2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85063-4-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using BAG2 Recombinant antibody (85063-4-RR)

    WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85063-4-RR (BAG2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85063-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85063-4-RR

    Affinity and Kinetic Characterization of 85063-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85063-4-RR against Human BAG2 were performed. The affinity constant is 0.644 nM.

Informations sur le produit

85063-4-PBS cible BAG2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène BAG2 Protéine recombinante Ag30873
Nom complet BCL2-associated athanogene 2
Masse moléculaire calculée 24 kDa
Poids moléculaire observé25 kDa
Numéro d’acquisition GenBankNM_004282
Symbole du gène BAG2
Identification du gène (NCBI) 9532
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

BAG2 (BAG family molecular chaperone regulator 2) is one of six proteins in mammals that contain the BAG domain, which belongs to the BAG (Bcl-2-associated athanogene) family. BAG2 has been described as a negative regulator of the chaperone-associated ubiquitin ligase C terminus of Hsc70-interacting protein (CHIP) that participates in the ubiquitin-mediated proteasomal degradation of misfolded substrate proteins (PMID: 16207813). BAG2 is widely expressed in human tissues, including brown adipose, heart and lung tissue, as well as in various types of tumor cells, including renal cell carcinoma, glioblastoma and thyroid carcinoma cells (PMID: 28536620). BAG2 overexpression is associated with poor prognosis in patients and mutp53 accumulation in tumors (PMID: 26271008).

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