Anticorps Polyclonal de lapin anti-BCAM

BCAM Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33665-1-PBS

Synonymes

Basal cell adhesion molecule, B-CAM cell surface glycoprotein, CD239, Gplu, Lu

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Galerie de données de validation

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  WB analysis using 33665-1-AP (same clone as 33665-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33665-1-AP (BCAM antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33665-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33665-1-PBS cible BCAM dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons rat, souris

• Réactivité: rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: BCAM Protéine recombinante Eg6306
• Nom complet: basal cell adhesion molecule
• Masse moléculaire calculée: 68 kDa
• Poids moléculaire observé: 67 kDa, 78-85 kDa
• Numéro d’acquisition GenBank: NM_020486.2
• Symbole du gène: Bcam
• Identification du gène (NCBI): 57278
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Basal cell adhesion molecule (Lu/BCAM) is a membrane-bound glycoprotein of the immunoglobulin superfamily (IgSF), functioning as a receptor for the extracellular matrix protein, laminin. BCAM (Lutheran/basal cell-adhesion molecule, a glycoprotein) belongs to the immunoglobulin superfamily which contains both Lu blood group and BCAM tumor-associated antigens. Proteomics analysis suggests that BCAM might be a potential biomarker for pancreatic cancer (PMID: 19199705). BCAM, involved in cell adhesion and migration, can also promote tumor metastasis and has been elucidated to play a functional role in the metastasis of thyroid cancer and gastric cancer (PMID: 10728810, 35941663). De-glycosylated BCAM has a preidicted molecular weight of 67 kDa. Two BCAM glycoprotein (gp) isoforms are present on human RBCs, Lu (85 kDa) and Lu(v13) (78 kDa); they result from the alternative splicing of intron 13 and differ by the lengths of their cytoplasmic domains (PMID: 23160466).

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