Anticorps Polyclonal de lapin anti-BCL11A

BCL11A Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11613-1-PBS

Synonymes

B cell lymphoma/leukaemia 11A, B-cell CLL/lymphoma 11A, B-cell lymphoma/leukemia 11A, BCL-11A, COUP-TF-interacting protein 1

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Galerie de données de validation

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  WB analysis using 11613-1-AP (same clone as 11613-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11613-1-AP (BCL11A antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse spleen using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11613-1-PBS cible BCL11A dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: BCL11A Protéine recombinante Ag2187
• Nom complet: B-cell CLL/lymphoma 11A (zinc finger protein)
• Masse moléculaire calculée: 835 aa, 91 kDa
• Numéro d’acquisition GenBank: BC021098
• Symbole du gène: BCL11A
• Identification du gène (NCBI): 53335
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

B-CELL CLL/LYMPHOMA 11A(BCL11A)is a highly conserved zinc finger gene. It acts as a myeloid and B-cell proto-oncogene, and may play key roles in leukemogenesis and hematopoiesis. It is an essential factor in lymphopoiesis, and required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. It is also involved in lymphoid malignancies through translocation or amplification events. It has recently been shown that BCL11A expression is inversely correlated with γ globin expression.(PMID:21156846). This is a rabbit polyclonal antibody raised against part chain of N-terminal BCL11A of human origin. There are three isoforms of BCL11A: isoform1(773aa), isoform2(486aa) and isoform3(239aa)

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