Anticorps Recombinant de lapin anti-BCL2L13

BCL2L13 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250705F1

N° de cat : 86183-1-PBS

Synonymes

Bcl2-L-13, Bcl-2-like protein 13, Bcl-rambo, CD003, MIL 1

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Galerie de données de validation

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  WB analysis using 86183-1-RR (same clone as 86183-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86183-1-RR (BCL2L13 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86183-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86183-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86183-1-RR against Human BCL2L13 were performed. The affinity constant is 1.32 nM.

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Informations sur le produit

86183-1-PBS cible BCL2L13 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: BCL2L13 Protéine recombinante Ag9841
• Nom complet: BCL2-like 13 (apoptosis facilitator)
• Masse moléculaire calculée: 485 aa, 53 kDa
• Poids moléculaire observé: 85 kDa
• Numéro d’acquisition GenBank: BC003032
• Symbole du gène: BCL2L13
• Identification du gène (NCBI): 23786
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

BCL2L13/MIL1 gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. BLC2L13 gene is highest expressed in heart, placenta and pancreas. The encoded protein Bcl-rambo may promote the activation of caspase-3 and apoptosis. The Bcl-rambo cell death activity was induced by its membrane-anchored C-terminal domain and not by the Bcl-2 homology region (PMID: 11262395). Multivariate analysis demonstrated that high expression of BCL2L13 was an independent prognostic factor for in childhood acute lymphoblastic leukemia (PMID: 20109966).

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