Anticorps Polyclonal de lapin anti-SURVIVIN-Specific

SURVIVIN-Specific Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

ELISA

Conjugaison

Non conjugué

N° de cat : 19119-1-AP

Synonymes

API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN

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Galerie de données de validation

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  WB analysis of HeLa using 19119-1-AP

  HeLa cells were subjected to SDS PAGE followed by western blot with 19119-1-AP (SURVIVIN-Specific antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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  IHC staining of human colon cancer using 19119-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human colon cancer using 19119-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human lung cancer using 19119-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human lung cancer using 19119-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human pancreas cancer using 19119-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human pancreas cancer using 19119-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 40x lens).

• 

  IF Staining of HeLa using 19119-1-AP

  Immunofluorescent analysis of HeLa cells using 19119-1-AP (SURVIVIN-Specific antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

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Informations sur le produit

19119-1-AP cible SURVIVIN-Specific dans les applications de ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: baculoviral IAP repeat-containing 5
• Masse moléculaire calculée: 18 kDa
• Numéro d’acquisition GenBank: NM_001168
• Symbole du gène: Survivin
• Identification du gène (NCBI): 332
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

BIRC5, also named as API4 and IAP4, is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. BIRC5 may play a role in neoplasia and counteract a default induction of apoptosis in G2/M phase. The antibody can recognize all these isoforms of BIRC5.

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