Anticorps Polyclonal de lapin anti-BMP2K

BMP2K Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32853-1-PBS

Synonymes

BIKe, BMP-2-inducible protein kinase, EC:2.7.11.1, HRIHFB2017

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Galerie de données de validation

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  WB analysis using 32853-1-AP (same clone as 32853-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32853-1-AP (BMP2K antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32853-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32853-1-PBS cible BMP2K dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: BMP2K Protéine recombinante Ag36482
• Nom complet: BMP2 inducible kinase
• Masse moléculaire calculée: 129kDa，1161aa
• Poids moléculaire observé: 140 kDa
• Numéro d’acquisition GenBank: NM_198892.1
• Symbole du gène: BMP2K
• Identification du gène (NCBI): 55589
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

BMP2K is an uncharacterized member of NAK family. Structural similarities of kinase domains (75% identical) and in vitro inhibition profiles categorized BMP2K as the closest homolog of AAK1. BMP2K was originally identified as a serine-threonine kinase regulating osteoblast differentiation whose gene product is sharply upregulated by BMP-2 stimulation. Later, various genetic and proteomic screens linked BMP2K to HIV entry, developmental dysplasia of the hip, myopia, leukemia, breast cancer metastasis and so on. Recent multivariate proteomic profiling approaches identified BMP2K as a component of purified CCV from HeLa cells. BMP2K can phosphorylate AP-2 in vitro and in vivo. Functional impairment of BMP2K impedes AP-2 phosphorylation leading to defects in clathrin-coated pit (CCP) morphology and cargo internalization. BMP2K engages AP-2 via its extended C-terminus and this interaction is important for its CCP localization and function (PMID: 34480404).

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