Anticorps Polyclonal de lapin anti-BMPR2

BMPR2 Polyclonal Antibody for IP, WB,ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IP, IF, ELISA

Conjugaison

Non conjugué

Publications

9

N° de cat : 14376-1-AP

Synonymes

BMP type 2 receptor, BMP type II receptor, BMPR 2, BMPR II, BMPR2, BMPR3, BMR2, BRK 3, PPH1, T ALK

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Galerie de données de validation

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  WB analysis using 14376-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 14376-1-AP (BMPR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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  IP experiment of mouse brain using 14376-1-AP

  IP Result of anti-BMPR2 (IP:14376-1-AP, 4ug; Detection:14376-1-AP 1:500) with mouse brain tissue lysate 6500ug.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris,
• Résultats positifs en IP: tissu cérébral de souris

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000
• Immunoprécipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 9 publications below
• IF: See 1 publications below

Informations sur le produit

14376-1-AP cible BMPR2 dans les applications de WB, IP, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: BMPR2 Protéine recombinante Ag5752
• Nom complet: bone morphogenetic protein receptor, type II (serine/threonine kinase)
• Masse moléculaire calculée: 115 kDa
• Poids moléculaire observé: 120 kDa
• Numéro d’acquisition GenBank: BC052985
• Symbole du gène: BMPR2
• Identification du gène (NCBI): 659
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

BMPs (bone morphogenetic protein) are involved in endochondral bone formation and embryogenesis. BMPR2 encodes a member of the (BMP) receptor family of transmembrane serine/threonine kinases. It is a widely expressed receptor, with high mRNA expression during development in many tissues. Dimer of BMPR2 receptors (70-80 kD) forms a complex with a dimer of type I BMPR1(50-55 kD) in signal transduction. This antibody recognizes endogenous levels of total BMPR2 protein, including 115 kD precursor, 75 kD mature form and 150 kD dimer.

Publications

Species	Application	Title
rat	WB	Front Pharmacol; Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway; Authors - Lijun Li
human	WB	BMC Genomics; Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells.; Authors - Jidong Chen
mouse	WB	BMC Complement Med Ther; Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway; Authors - Ying Chen
mouse	WB	Exp Gerontol; AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling.; Authors - Guorong Deng
human	WB	Biochem Biophys Res Commun; SPG6 supports development of acute myeloid leukemia by regulating BMPR2-Smad-Bcl-2/Bcl-xl signaling.; Authors - Jinliang Chen
rat	WB	Sci Rep; Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.; Authors - Yan Zeng

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