Anticorps Polyclonal de lapin anti-BRWD3

BRWD3 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31795-1-PBS

Synonymes

Bromodomain and WD repeat-containing protein 3

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Galerie de données de validation

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  WB analysis using 31795-1-AP (same clone as 31795-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31795-1-AP (BRWD3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31795-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31795-1-PBS cible BRWD3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: BRWD3 Protéine recombinante Ag36948
• Nom complet: bromodomain and WD repeat domain containing 3
• Masse moléculaire calculée: 204 kDa
• Poids moléculaire observé: 240 kDa
• Numéro d’acquisition GenBank: BC039508
• Symbole du gène: BRWD3
• Identification du gène (NCBI): 254065
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Bromodomain and WD repeat-containing protein 3 (BRWD3) is thought to regulate gene expression through its interactions with chromatin. BRWD3 promotes the K48-linked polyubiquitination and degradation of KDM5, which depends on BRWD3 and Cul4. This function is critical for maintaining H3K4 methylation levels and regulating gene expression (PMID: 37722046). Mutations of BRWD3 are associated with a spectrum of cognitive disabilities and X-linked macrocephaly (PMID: 17668385).

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