Anticorps Recombinant de lapin anti-BST2

BST2 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250317H5

N° de cat : 98305-2-PBS

Synonymes

CD317, Bone marrow stromal antigen 2, BST 2, BST-2, CD 317

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Galerie de données de validation

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  FC experiment of human PBMCs using 98305-2-RR (same clone as 98305-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human BST2 Rabbit RecAb (98305-2-RR, Clone: 250317H5) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98305-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98305-2-RR (same clone as 98305-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human BST2 Rabbit RecAb (98305-2-RR, Clone: 250317H5) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98305-2-PBS in a different storage buffer formulation.

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Informations sur le produit

98305-2-PBS cible BST2 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: BST2 Protéine recombinante Eg1961
• Nom complet: bone marrow stromal cell antigen 2
• Masse moléculaire calculée: 180 aa, 20 kDa
• Numéro d’acquisition GenBank: BC033873
• Symbole du gène: BST2
• Identification du gène (NCBI): 684
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

BST2, also named as CD317 and Tetherin, belongs to the tetherin family. It may be involved in the sorting of secreted proteins and it is involved in pre-B-cell growth. BST2 is an antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. BST2 may play a role in B-cell activation in rheumatoid arthritis. It is recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. BST2 is a plasma membrane proteins, tetherin inhibits virion particle release from infected cells. BST2 is effective against retroviruses and flavoviruses whilst IFITMs disrupt influenza and flavivirus infection. Observed MW of BST2 is 30-36 kDa (PMID: 19196977; 21237475).

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